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梁剛荐 副教授 Max K. Leong |
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聯絡方式 |
研究室：(03)-863-3609 |
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辦公室 |
理D419 |
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Office Hour |
禮 拜三 14:00-16:00 |
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實 驗室個別網頁網址 |
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主要學歷 |
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美
國德州大學化學物理博士 |
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現職經歷 |
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美國德州大學 研究員 國 家衛生研究院 助研究員 太景生物科技公司 研究員 國立東華大學化學系副教授
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研究方向 |
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1. 化學資訊學、分子模擬、電腦輔助藥物 設計/分子設計、機器學習應用 2. 本實驗室目前的研究是 ADME/Tox in silico and drug discovery。歡迎有化學、生化、生物、藥物化學 或物理相關背景的人員加入本實驗室 |
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學術著作 |
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1、 Shia, K.-S.; Li, W.-T.; Chang, C.-M.; Hsu, M.-C.; Chern, J.-H.; Leong, M. K.; Tseng, S.-N.; Lee, C.-C.; Lee, Y.-C.; Chen, S.-J.; Peng, K.-C.; Tseng, H.-Y.; Chang, Y.-L.; Tai, C.-L.; Shih, S.-R., Design, Synthesis, and Structure-Activity Relationship of Pyridyl Imidazolidinones: A Novel Class of Potent and Selective Human Enterovirus 71 Inhibitors. J. Med. Chem. 2002, 45, 1644 -1655.
2、 Hakimelahi, G. H.; Li, P. C.; Moosavi-Movahedi, A. A.; Chamani, J.; Khodarahmi, G. A.; Ly, T. W.; Valiyev, F.; Leong, M. K.; Hakimelahi, S.; Shia, K. S.; Chao, I., Application of the Barton Photochemical Reaction in the Synthesis of 1-Dethia-3-Aza-1-Carba-2-Oxacephem: A Novel Agent Against Resistant Pathogenic Microorganisms. Org. Biomol. Chem. 2003, 1, 2461-2467.
3、 Liu, H.-C.; Lyu, P.-C.; Leong, M. K.; Tsai, K.-C.; Hsiue, G.-H., 3D-QSAR Studies on PU3 Analogues by Comparative Molecular Field Analysis. Bioorg. Med. Chem. Lett. 2004, 14, 731-734.
4. Max K. Leong*, 2007/2: “A Novel Approach Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) for Prediction of hERG Liability,” Chem. Res. Toxicol., 20 (2), 217-226. (SCI)
5. Max K. Leong, Chinpiao Chen, Ker-Chang Shar, and David Shiuan*, 2007/9: “Selection and characterization of lipase abzyme from phage displayed antibody libraries,” Biochem. Biophys. Res. Commun., 361 (3), 567-573. (SCI)
6. S. J. Hsu, K. M. Hsu, Max K. Leong and Ivan J. B. Lin*, 2008/4: “Au(I)-benzimidazole/imidazole complexes. Liquid crystals and nanomaterials,” Dalton Trans., No. 14, 1924-1931. (SCI)
7. Max K. Leong* and Tzu-Hsien Chen, 2008/7: “Prediction of Cytochrome P450 2B6-Substrate Interactions Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) Approach,” Med. Chem., 4(4), 396-406.
8. Max K. Leong*, Yen-Ming Chen, Hong-Bin Chen, and Po-Hong Chen, 2009/4: “Development of a New Predictive Model for Interactions with Human Cytochrome P450 2A6 Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) Approach,” Pharm. Res., 26(4), 987-1000. (SCI)
9. Max K. Leong*, Yen-Ming Chen, and Tzu-Hsien Chen, 2009: “Prediction of Human Cytochrome P450 2B6-Substrate Interactions Using Hierarchical Support Vector Regression Approach,” J. Comput. Chem., 30(12), 1899-1909. (SCI)
10. Chiou, Ling-Song; Ching-Shiang Fang; Bijay Sarkar; Ling-Kang Liu; Max K. Leong* and C. W. Liu*, 2009: “Reactivities of Secondary Phosphine Selenides Cp(CO)2FeP(Se)(OR)2: Formation of a Diiodine Charge Transfer Adduct and Se-Methylation,” Organometallics,28(17), 4958-4963. (SCI)
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