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陳清漂 副教授
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聯絡方式 |
研究室：(03)-863-3597 |
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辦公室 |
理D317 |
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Office Hour |
禮拜二 13:00-15:00 |
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實驗室個別網頁網址 |
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主要學歷 |
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美國匹茲堡大學化學系博士(1988-1992)【指導教授Prof.
Kozikowski, A. P.】 |
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現職經歷 |
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美國哈佛大學化學系博士後研究員(1993-1995)【指導教授Prof. Kishi, Y.】 工研院材料所研究員(1995) 慈濟大學醫技系副教授(1995-2001) 國立東華大學化學系助教授(2001-2003 ) 國立東華大學化學系副教授(2003/8-
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研究方向 |
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1. 不對稱合成反應 2. 藥物與天然物合成
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反應的開發與探討 |
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學術著作 |
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1.Kozikowski, A. P.; Chen, C. 1990, “An Unusual Fragmentation Process Discovered During the Course of Cleavage of a Camphanic Acid Amide”, Tetrahedron Lett. 31, 5869-5872.
2. Chen, C.; Kozkowski, A. P.; Wood, P. L.; Reynolds, I. J.; Ball, R. G.; Pang, Y.-P. 1992, “Synthesis and Biological Activity of 8a-Phenyl-decahydroquinolines as Probes of PCP,s Binding Conformation. A New PCP-like Compound with Increased in vivo Potency”, J. Med. Chem. 35, 1634-1638.
3. Kozikowski, A. P.; Ognyanov, V. I.; Chen, C.; Kurian, P.; Crews, F. T. 1993, “Synthesis and Binding Studies of an Optically Pure Hexadeoxy-1,4,5-tris(methylenesulfonic acid) Analogue of IP3”, Tetrahedron Lett. 34, 219-222.
4. Kozikowski, A. P.; Chen, C.; Wu, J.-P.; Shibuya, M.; Kim, C.-G.; Floss, H. G. 1993, “Probing Ergot Alkaloid Biosynthesis: Intermediates in the Formation of Ring C”, J. Am. Chem. Soc. 115, 2482-2488.
5. Kozikowski, A. P.; Ognyanov, V. I.; Chen, C.; Fauq, A. H.; Safrant, S. T.; Wilcox, R. A.; Nahorski, S. R.; 1993, “Deoxygenated Inositol 1,4,5-Triphosphate Analogues and Their Interaction with Metabolic Enzymes. (1R,2R,4R)-Cyclohexane-1,2,4-tris(methylenesulfonate): A Potent Selective 5-Phosphatase Inhibitor”, J. Med. Chem. 36, 3035-3038.
6. Chen, C.; Tagami, K.; Kishi, Y. 1995, “Ni(II)/Cr(II)-Mediated Coupling Reaction. Asymmetric Process”, J. Org. Chem. 60, 5386-5387.
7. Chen, C.* 1998, “NiCl2/CrCl2-Mediated Coupling Reaction of Ketones with Alkenyl(or Alkynyl, Aryl) Halides Accomplished in the Presence of Bipyridyl-type Ligand” SYNLETT, 1311-1312.
8. Chen, C.* 2000, “NiCl2/CrCl2/Mn-Mediated Homocoupling of Aryl Halides Accomplished in the Presence of Bipyridyl-type Ligand” SYNLETT, 1491-1493.
9. Chen, C.*; Chien, C.-T.; Su, C.-H. 2002, “Preparation of acyl fluorides with hydrogen fluoride- pyridine and 1,3-dicyclohexylcarbodiimide” J. Fluorine Chem. 115, 75-77.
10. Chen, C.*; Dai, W.-C.; Chang, H.-G. 2002, “A Facile and Efficient Zinc-Promoted Allylation of Carbonyl Compounds” Org. Prep. Proced. Int. 34, 471-475.
11. Chen, C.*; Liu, Y.-Z.; Shia, K.-S.; Tseng, H.-Y. 2002, “Synthesis and Anticancer Evaluation of Vitamin K3 Analogues” Bioorg. Med. Chem. Lett. 12, 19, 2729-2732.
12. Chen, C.*; Chen, Y.-J. 2004, “Liquid-phase synthesis of 2-substituted benzimidazoles, benzoxazoles and benzothiazoles” Tetrahedron Lett. 45, 1, 113-115.
13. Wang,G.-J.; Lai, T.-C.; Tzen, H.-R.; Chen, C.* 2004, “Inhibitory Effects of L-Arginine Derivatives on Endothelium-Dependent Vasorelaxing Response to Acetylcholine of the Rat Aorta” Eur. J. Med. Chem. 39, 7, 611-617.
14. Chen, Y.-J.; Lin, R.-X.; Chen, C.* 2004, “Synthesis of C2-symmetric chiral bipyridyldiol and its application in the enantioselective addition of diethylzinc to substituted benzaldehydes” Tetrahedron: Asymmetry 15, 22, 3561-3571.
15. Lee, P.-T.; Chen, C.* 2005, “A C2-symmetric chiral bipyridyldiol-titanium complex as the catalyst for asymmetric trimethylsilylcyanation of substituted benzaldehydes” Tetrahedron: Asymmetry 16, 16, 2704-2710.
16. Lin, R.-X.; Chen, C.* 2006, “Chiral 8-substituted 10,10-dimethyl-5-pyridin-2-yl-6-aza- tricyclo [7.1.1.02,7]undeca-2(7),3,5-trien-8-ols as enantioselective catalysts in the addition of diethylzinc to substituted benzaldehydes” J. Mol. Catal. A-Chem. 243, 89-98.
17. Chen, Y.-J.; Chen, C.* 2006, “The influence of electronic effects on the enantioselective reactions” Chemistry, 64, 1, 35-60.
18. Huang, S.-T.; Hsei, I.-J.; Chen, C.* 2006, “Synthesis and Anticancer Evaluation of Bis(benzimidazoles), Bis(benzoxazoles), and Benzothiazoles” Bioorg. Med. Chem. 14, 17, 6105-6118.
19. Xu, Y.-Z.; Chen, C.* 2006, “Synthesis of deuterium labelled standards of 5-methoxy-N,N- dimethyltryptamine (5-Meo-DMT)” J. Labelled. Comp. Rad. 49, 10, 897-902.
20. Xu, Y.-Z.; Chen, C.* 2006, “Synthesis of deuterium labelled of phenethylamine derivatives” J. Labelled. Comp. Rad. 49, 13, 1187-1200.
21. Xu, Y.-Z.; Chen, C.* 2007, “Syntheses of deuterium labeled 2,5-dimethoxyamphetamine (DMA), 4-bromo-2,5-dimethoxyamphetamine (DOB), and 4-methoxyamphetamine (PMA) as internal standards for quantitative analyses by GC-MS” J. Chin. Chem. Soc. 54, 2, 493-502.
22. Liu, S.-Y.; Lo, C.-T.; Chen, C.; Liu, M.-Y.; Chen, J.-H.; Peng K.-C.* 2007, “Efficient Isolation of Anthraquinone-Derivatives from Trichoderma harzianum ETS 323” J. Biochem. Bioph. Meth. 70, 391-395.
23. Shaikh, A. C.; Wang, Y.-Y.; Chen, C.* 2007, “Synthesis of deuterium labelled standards of (±)-DOM and (±)-MMDA” J. Labelled. Comp. Radiopharm. 50, 7, 660-665.
24. Chen, Y.-J.; Chen, C.* 2007, “Enantioselective ring-opening reaction of meso-epoxide with ArSH catalyzed by a C2-symmetric chiral bipyridyldiol-titanium complex” Tetrahedron: Asymmetry 18, 11, 1313-1319.
25. Leong, M.; Chen, C.; Shar, K. C.; Shiuan, D.* 2007, “Selection and characterization of lipase abzyme from phage displayed antibody libraries” Biochem. Biophys. Res. Commun. 361, 567–573. (2007.9)
26. Chen, Y.-J.; Chen, C.* 2007, “Synthesis of deuterium labelled standards of dihydroetorphine and etorphine” J. Labelled. Comp. Radiopharm. 50, 1143-1147. (2007.11)
27. Wang, Y.-Y.; Chen, C.* 2007, “Synthesis of deuterium labelled tryptamine derivatives” J. Chin. Chem. Soc. 54, 5, 1363-1368. (2007.10)
28. Wang, Y.-Y.; Chen, C.* 2007, “Synthesis of deuterium labelled standards of bufotenine (5- HO-DMT)” J. Labelled. Comp. Radiopharm. 50, 14, 1262-1265. (2007.12)
29. Chang, T.-C.; Chen, C.* 2008, “Synthesis of chiral (5-heteroaryl-10,10-dimethyl-6-aza- tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-8-yl)-diphenyl-methanols and their application in the enantioselective addition of diethylzinc to substituted benzaldehydes” J. Chin. Chem. Soc. 55, 3, 606-615. (2008.6)
30. Shaikh, A. C.; Chen, C.* 2008, “Synthesis of deuterium labeled zaleplon-d5 as an internal standard”, J. Labelled. Comp. Radiopharm.51, 72-76. (2008.1.14)
31. Hsua,T.-S.; Chen, C.; Lee, P.-T.; Chiu, S.-J.; Liua, H.-F.; Chao, J.-I.* 2008, “7-Chloro-6- piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53- independent pathway” Cancer Chemoth. Pharm. 62, 799-808. (2008.10.)
32. You, Z.-Y.; Chen, Y.-J.; Wang, Y.-Y.; Chen, C.* 2008, “Synthesis of Deuterium Labelled Standards of 1-Benzylpiperazine, Fenetylline, Nicocodeine and Nicomorphine” J. Chin. Chem. Soc. 55, 3, 663-667. (2008.6)
33. Xu, Y.-Z.; Lin, H.-R. Lua, A.-C.; Chen, C.* 2008, Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards. J. Serb. Chem. Soc. 73, 12, 1223- 1233. (2008.12).
34. Chen, Y.-J.; Chen, C.* 2008, Catalytic enantioselective Strecker-type reaction of phosphinoyl ketimines by bipyridyldiol derived chiral zirconium catalysts. Tetrahedron: Asymmetry, 19, 18, 2201-2209. (2008.9.22)
35. Srimurugan, S.; Murugan, K.; Chen, C.* 2009, A Facile Method for the Preparation of [2H3]- Sufentanil and Its Metabolites. Chem. Pharm. Bull. 57, 12, 1421-1424.
36. Zheng, W.-W.; Hsieh, Y.-H.; Chiu, Y.-C.; Cai, S.-J.; Cheng, C.-L.*; Chen, C.* 2009, Organic functionalisation of ultradispersed nanodiamond: Synthesis and applications. J. Mater. Chem. 19, 8432-8441.
37. Huang, X.-R.; Chen, C.*; Lee, G.-H.; Peng, S.-M. 2009, A Spirocyclic Chiral Borate for Catalytic Enantioselective Nozaki-Hiyama Allylation of Ketones. Adv. Syn. Catal. 351, 3089- 3095.
38. 以含氘化合物作為藥物檢驗之標準品及其製備方法(中華民國專利)。專利號碼： 1318621。 發明人；陳清漂，許雅筑。專利權人：行政院衛生署管制藥品管理局 (2009)。
39. Murugan, K.; Srimurugan, S.; Chen, C.* 2010, A mild, catalytic and efficient Nazarov cyclization mediated by phosphomolybdic acid. Chem. Commun. 46, 1127-1129. |
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