何彥鵬  教授
Yen-Peng Ho

聯絡方式

研究室：(03)-863-3591
實驗室：(03)-863-3592

辦公室

理D418

Email

ypho@mail.ndhu.edu.tw

Office Hour

禮拜四 15:00-17:00

  實驗室個別網頁網址

 http://faculty.ndhu.edu.tw/~yphoweb/HoHomePage.htm

  主要學歷

                    
凱斯西儲大學 (Case Western Reserve University) 化學系 博士 1996

國立中興大學 化學系 學士 1986
　

  現職經歷

Colorado School of Mines, Research Associate 1996-1997

University of Maryland, Research Associate 1997-1999

國立東華大學化學系 助理教授 1999-2003

國立東華大學化學系 副教授 2003-2007

國立東華大學化學系 教授 2007-
　

  研究方向

質譜儀(MS)是最為廣泛使用的分析工具之一。它是測量離子（帶電的分子）質量的儀器，目前在生物及醫學相關的研究上相當重要，我們實驗室主要的工作就是以質譜儀為工具進行各種生化分析的研究，下列為主要的研究方向：

1.          蛋白體研究

2.          微生物的分析與鑑定

3.          蛋白質結構分析（氫/氘交換，串聯質譜技術）

4.          各類磷脂結構鑑定

5.          磷脂與生物活性關係之探討
　

  學術著作

期刊論文：

1.  Li, Y.-Z.; Ho, Y.-P.; Chen, S.-T.; Chiou, T.-W.; Li, Z.-S.; Shiuan, D. “Proteomic comparative analysis of pathogenic strain 232 and avirulent strain J of Mycoplasma hyopneumoniae”Biochemsitry-Moscow 2009, 74 , 215-220.

2.Ho, Y.-P.* ; Reddy, M.; Chen, C.-T. and Lo, A. A.-L. “Applications of mass spectrometry in microbial forensics”Forensic Science Review 2009, 21, 25-50. (invited review article)

3.  Reddy, p. M.; Ho, Y.-P.*; Shanker K.; Rohini, R.; Ravinder, V.* “Physicochemical and biological characterization of novel macrocycles derived from o-phthalaldehyde” European Journal of Medicinal Chemistry 2009, 44, 2621-2625.

4.  Shanker K.; Rohini, R.; Ravinder, V.*; Reddy, P. M.; Ho, Y.-P.* “Ru(II) complexes of N4 and N2O2 macrocyclic Schiff base ligands: Their antibacterial and antifungal studies”Spectrochimica Acta Part A 2009, 73, 205–211.

5.  Rohini, R.; Shanker, K.; Reddy, P. M.; Ho, Y.-P*.; Ravinder, V., Mono and bis-6-arylbenzimidazo[1,2-c]quinazolines: A new class of antimicrobial agents. European Journal of Medicinal Chemistry 2009, 44, 3330–3339.

6.    Ho, Y.-P.* and Reddy, M. “Mass spectrometry-based approaches for the detection of proteins of Staphylococcus species”Infectious Disorders-Drug Targets 2008, 8, 166-182. (Invited review article).

7.  Sun, M.-C.; Chen, C.-D.; Huang, Y.-S.; Wu, Z-S. and Ho, Y.-P.* “Matrix Assisted Laser Desorption/Ionization-MS-Based Relative Quantification of Peptides and Proteins using Iodoacetamide and N-Methyliodoacetamide as Labeling Reagents” J. Sep. Sci. 2008, 31, 538-547.

8.  Chang, C.-C.;Chen, P.-H.; Chu, H.-L.; Lee, T.-C.; Chou, C.-C.; Chao, J.-I.; Su, C.-Y.; Chen, J.-S., J.-S.; Tsai, C.-M.; Ho, Y.-P.; Sun, K.-W.; Cheng, C.-W.; Chen, F.-R. “Laser induced popcornlike conformational transition of nanodiamond as a nanoknife” Appl. Phys Lett. 2008, 93, 033905.

9.  Liu, K.-K.; Chen, M.-F.; Chen, P.-Y.; Lee, T.; Cheng, C.-L.; Chang, C.-C.; Ho, Y.-P.; Chao, J.-I. “Alpha-bungarotoxin binding to target cell in a developing visual system by carboxylated nanodiamond” Nanotechnology, 2008, 19, 205102.

10. Hu, A.; Lo, A. A.-L.; Chen, C.-T.; Lin, K.-C.; Ho, Y.-P.* “Identifying Bacterial Species using Electrophoresis–Mass Spectrometry and SEQUEST with an Empirical Scoring Function”Electrophoresis. 2007, 28, 1387-1392.

11. Yang, M.-W.; Chen, L.-T.; Yang, Y.-C.*; Ho, Y.-P.* “Determining the Relative Bond Dissociation Energies of the Sodium Salts of Amino Acids by Mass Spectrometry and the Kinetic Method”J. Mass Spectrom. 2007, 42, 542-544.

12. Ho, Y.-P.; Yang, M.-W.; Chen, L.-T.; Yang, Y.-C.* “Relative Calcium Binding Strengths of Amino Acids Determined Using the Kinetic Method”Rapid Commun. Mass Spectrom. 2007, 21, 1083-1089.

13. Chang, C.-C.; Chao, J.-I.; Ho, Y.-P. ; Sun, K.-W.; Cheng, C.-L. “Nano-manipulation on cancer cells by protein-nanodiamond complex” Biophys. J. 2007, 332A-332A Suppl. S 14.

14.  Hu, A.; Chen, C.-T.;Tsai, P.-J.; Ho, Y.-P.* “Using Capillary Electrophoresis–Selective Tandem Mass Spectrometry to Identify Pathogens in Clinical Samples” Anal. Chem. 2006, 78, 5124-5133.

15.  Lo, A. A.-L.; Hu, A.; Ho, Y.-P.* “Identification of Microbial Mixtures by LC-Selective Proteotypic-peptide Analysis (SPA)” J. Mass Spectrom. 2006, 41,1049-1060.
　

16.  Hu, A.; Tsai, P.-J.; Ho, Y.-P.* “Identification of Microbial Mixtures by Capillary Electrophoresis/Selective Tandem Mass Spectrometry” Anal. Chem. 2005, 77, 1488-1495.

17.  Lin, S.-S.; Wu, C.-H.; Sun, M.-C.; Sun, C.-M.; Ho, Y.-P.* Microwave-Assisted Enzyme-Catalyzed Reactions in Various Solvent Systems J. Am. Soc. Mass Spectrom. 2005, 16, 581-588.

18.  Chang, C.-C.; Lin, P.-Y.; Yeh, X.-C.; Deng, K.-H.; Ho, Y.-P.; Kan L.-S. Protein folding stabilizing time measurement: A direct folding process and three-dimensional random walk simulation Biochem. Biophys. Research Commun. 2005, 328, 845–850.

19.  Wang, Y.F.; Ho, M.-Y.; Ho, Y.-P.* Using mass spectrometry to probe the subtle differences in conformations of several different cytochromes c in aqueous and methanol solutions J. Mass Spectrom. 2004 , 39, 1523-1570.

專利：

1.      Use of Matrices Comprising Liquids and Light Absorbing Particles for Analysis of Microorganisms by Laser Desorption Mass Spectrometry USA5948610