Jia -Liang Zhu

　

Associate Professor,  Organic Chemistry

Phone: 03-8633583 (O) 03-8633584 (Lab)

Fax: 03-863-3570 

Room:  D310 science building. 

Home Page   

E-mail: jlzhu@mail.ndhu.edu.tw

office hour: 15:00-17:00, Thursday

National Dong Hwa University, Shou-Feng, Hualien, 974,  Taiwan

                                                   

  • Education

B. S., Pharmacy Department of Medical School, Lanzhou University (1989)

Ph. D., University of Alberta (1999)
　

  • Experience

Postdoctoral Fellow, University of Calgary (1999-2000);

National Tsing Hua University (2000-02)

Associated Investigator, Taigen Biotechnology (2002-05)

Assistant Professor, Department of Chemistry, National Dong Hwa University (2005-2009)

Associate Professor, Department of Chemistry, National Dong Hwa University (2009-)

　

  • Research Interests
   We are involved in research in two major areas of organic synthesis: 1) development of new synthetic methods and application of these methods into total synthesis of natural products, 2) design and synthesis of biologically active compounds as potential drug candidates.
　
  • Patent

K. S. Shia, G. H. Hakimelahi, J. L. Zhu, C. F. Yen, Y. H. Huang and Y. B. Xiang: “Polyamine compounds for treating chemokine receptor mediated diseases ", US patent, US 2005/ 0043366 A1, Feb. 24, 2005.

　

  • Selected Publications

    　

    1. Chuan-Cheng Liao and Jia-Liang Zhu*, “Investigation on Lewis Acid Mediated Diels-Alder Reactions of 2-Phosphono-2-alkenoates. Application to Total Synthesis of (±)-α-Alasken-8-one via Reductive Alkylation of Resulting Adduct,” J. Org. Chem., published on the web on September 17, 2009 (doi:10.1021/jo9017292) (SCI, IF = 3.95).
    2. Jia-Liang Zhu*, Yi-Lin Su, Yu-Hui Chan, I-Chia Chen and Chuan-Chen Liao, 2008: “Studies on the Amino-Heck Reaction of Unsaturated Ketone O-Phosphinyloximes for the Preparation of Substituted Pyridines,” Heterocycles, accepted (SCI, IF = 1.06).
    3. I-Chia Chen, Yen-Ku Wu, Hsing-Jang Liu*and Jiang-Liang Zhu*, “Total syntheses of (±)-montanin A and (±)-teuscorolide” Chem. Commun. 2008, 4720-4722 (SCI, IF = 5.14).
    4. Fa-Yen Lee and Jia-Liang Zhu*, “Novel and Efficient Procedure for the Regiocontrolled Preparation of α-(Phenylsulfanyl) Carbonyl Compounds” J. Chin. Chem. Soc., (Taiwan), 2008, 55 (3), 659-662 (SCI=0.64).
    5. Jia-Liang Zhu* and Yu-Hui Chan, “Palladium–Catalyzed Amino-Heck Reaction of γ,δ–Unsaturated Ketone O–Diethylphosphinyloximes. A New Synthesis of Substituted Pyrroles and Indoles”, Synlett, 2008, 8, 1250-1254 (SCI).
    6. Yen-Chun Ko and Jia-Liang Zhu*, “Efficient Preparation of a,a-Dialkyl a-Phenylseleno Acetates and a,b-Unsaturated Esters from the Corresponding a,a-Dialkyl a-Cyano Acetates”, Synthesis, 2007, 23, 3659-3666 (SCI: 2.33).
    7. Jia-Liang Zhu,* Fa-Yen Lee, Jen-Dar Wu, Chun-Wei Kuo, Kak-Shan Shia, “An Efficient New Procedure for the One-pot Conversion of Aldehydes into the Corresponding Nitriles”, Synlett 2007, 8, 1317-1319 (SCI: 2.83).
    8. Jia-Liang Zhu,* Yen-Jun Ko, Chun-Wei Kuo, Kak-Shan Shia,  “Lithium Naphthalenide Induced Reductive Selenenylation of α-Cyano Ketones. A Regiocontrolled Process for a-Phenylseleno Ketones and One-pot Conversion to Enone System”, Synlett 2007, 8, 1274-1278 (SCI: 2.83).
    9. C. W. Kuo, Jia-Liang Zhu, J. D. Wu, C. M. Chu, C. F. Yao and K. S.Shia, : “A Convenient New Procedure for Converting Primary Amides into Nitriles” Chem. Commun.,2007, 301-303.(SCI: 4.52).
    10. Jia-Liang Zhu, Yen-Jun Ko and Yi-Li Ding, “The Development of Inhibitors of the Hepatitis C Virus NS3-4A Serine Protease” CHEMISTRY, THE CHINESE CHEM. SOC., TAIPEI, 2006 64, No. 2, pp. 225-234.
    11. H. J Liu, Jia-Liang Zhu, I. C. Chen, R. Jankowska, Y. X. Han and K. S. Shia, : “The Total Synthesis of Racemic Teucvin and 12-epi-Teucvin” Angew. Chem. Int. Ed. 2003 42, 1851-1853. (SCI)
    12. G. H. Hakimelahi, A.A. Moosavi-Movahedi, T. Sambaiah, Jia-Liang Zhu, K. S. Ethiraj, M. Pasdar and T. Hakimelahi, : “Reactions of purines-containing butenolides with L-cysteine or N-acetyl-L-cysteine as model biological nucleophiles: a potent mechanism-based inhibitor of ribonucleotide reductase caused apoptosis in breast carcinoma MCF7 cells” Eur. J. Med. Chem. 2002,37, 207-217. (SCI)
    13. R. P. Pharis, L. Janzen, S. K. Nakajima, Jia-Liang Zhu and T.G. Back.  “Bioactivity of 25-hydroxy-, 26-hydroxy, 25,26-dihydroxy- and 25,26-epoxybrassinolide” Phytochemistry 2001,58,1043-1047. (SCI)
    14. Jia-Liang Zhu, K. S. Shia, and H. J. Liu,  “Diels-Alder Chemistry of 2-Cyano-2-alkenone. A Convenient General Approach to Angularly Substituted Polycyclic Systems” Chem. Commun. 2000,1599-1600. (SCI)
    15. T. G. Back, S. K. Nakajima and Jia-Liang Zhu,  “Synthesis of 25-Hydroxy-, 26-Hydroxy- and 25,26-Dihydroxybrassinolide” Synlett 11, 2000,1649-1651. (SCI)
    16. Zhu, Jia-Liang, Shia, Kak-Shan, Liu, Hsing-Jang, , Reductive Alkylation of Cyano Ketones Induced by Samarium Iodide, Tetrahedron Lett., 40, 1999,7055-7058.
    17. Shia, Kak-Shan, Jan, Ning-Wei, Zhu, Jia-Liang, Ly, Tai Wei, Liu, Hsing-Jang,  A facile two-carbon ring expansion process based on the 2-cyano-1-vinylcycloalkanol system, Tetrahedron Lett.,1999, 40, 6753- 6756.
    18. Liu, Hsing-Jang, Zhu, Jia-Liang, Shia, Kak-Shan, Lithium Naphthalenide Induced Reductive Alkylation of Cyano Ketones. A general Method for Regiocontrol of Dialkylation of Ketones, Tetrahedron Lett. 1998, 39, 4183-4186.